Ax-4 is commanded by Axiom's director of human spaceflight and former NASA astronaut Peggy Whitson. Joining her are Shubhanshu Shukla of India, Sławosz Uznański-Wiśniewski from Poland, and Tibor Kapu, from Hungary. The three will be the first astronauts from each of their nations to launch on a mission to the ISS.

NASA is in the process of rescheduling a commercial mission to the International Space Station after the postponement of a launch slated for Sunday.

NASA stated that it is taking additional time to evaluate the ISS's readiness, particularly after repair work in the aft (rear) section of the Zvezda service module, which is a critical component of the Russian segment of the space station.