Bone health relies on a balance between osteoblasts (builders) and osteoclasts (recyclers). Peak bone mass occurs in early adulthood; deficiencies during this window amplify fracture risks later in ...

Spontaneous osteoclastogenesis, a phenomenon characterized by the unregulated differentiation and activation of osteoclasts in the absence of exogenous stimulatory factors, plays a central role in ...

Rather than completely blocking all downstream signals, the peptide developed in this study focuses on inhibiting the activation of p38-MAPK. This is enough to downregulate the development of mature ...

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis. NELL2 promotes ...

I have reviewed the manuscript "Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast" with interest. The described findings are relevant and useful for daily ...

ABSTRACT: With the aging of the global population, bone degenerative diseases (such as osteoporosis) have become a major threat to the health of the elderly. The immune system plays a key role in the ...

This manuscript provides an important advance in our understanding of the molecular events that promote osteoclast fusion. Compelling data support the conclusion that an oxidized form of the ...

A team of researchers led by Osaka University find an overlap in the mechanism of hair color determination and bone resorption, which is associated with bone related diseases like osteoporosis Rab32 ...

Osteoclasts are bone‐resorbing polykaryons responsible for skeletal remodeling during health and disease. Coincident with their differentiation from myeloid precursors, osteoclasts undergo extensive ...

In an effort to identify new transcription factors (TFs) expression critical to osteoclast formation or function, mouse BMDMs and osteoclasts were harvested for transcriptional profiling. As expected, ...