The Buffalo Bills head into Week 17 fresh off a 23-20 win over the Cleveland Browns. The Bills have been at the top of NFL national power rankings polls most weeks throughout the 2025 season. Is this week going to be different?

Buffalo Bills fullback Reggie Gilliam was snubbed for a Pro Bowl spot this season, sparking some controversy after teams were announced.

Sal Maiorana’s take: The Bills have two key advantages: they’re at home and the game matters more for their playoff hopes. Buffalo is 16-1 at home since early 2024, while the Eagles—already locked into at least the No. 3 NFC seed—are strong on the road (5-3). It’ll be tough, but Sal believes the Bills will pull it off.

The NFL slate of games for Week 17 is set, and most of America will see the Bills host the Eagles in a massive Sunday afternoon showdown

"This time of year, it’s really important to stay on top of it because this is the home stretch and, a lot of the time, the team that’s healthier and playing together at the end of the year is the team that’s winning," Bosa added. "Trying not to think about it too much and continuing to stick with my process that I know puts me in the right spot."

NFL Week 17 talking points include a potential Super Bowl showdown and the Detroit Lions and Baltimore Ravens fighting to stay alive in their playoff pursuit.

This article originally appeared on Eagles Wire: Eagles vs. Bills: 7 X-factors from Buffalo's high-powered offense Two people were injured after U.S. Immigration and Customs Enforcement agents opened fire on a van in Maryland on Christmas Eve when the driver allegedly tried to run them over during a law enforcement operation, officials said.

The Buffalo Bills are heading to the playoffs for the seventh straight season. Buffalo clinched a postseason berth Monday night after the Indianapolis Colts lost to the San Francisco 49ers, officially locking the Bills into the AFC playoff field.