The Pats’ defense ranks Top 10 in many metrics. They are especially stout against the run, which could challenge the Bills and specifically, running back James Cook. The Bills’ bell cow back is the NFL’s second-leading rusher with 1,308yds (trails only Jonathan Taylor (1,356yds).

Kansas City's 16-13 loss to Los Angeles ends their chance to match Buffalo's record of four consecutive Super Bowl appearances, as the AFC championship race opens up.

Preview the Buffalo Bills' NFL week 15 matchup with the Patriots, including betting odds, tips, trends, and game information.