In this study, we employed unbiased lipidomic and transcriptomic approaches to investigate the contribution of IRE1α signalling to lipid metabolism in TNBC. This system biology framework enables the ...

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1Hummingbird Bioscience Pte Ltd, Singapore, Singapore.

Intracerebral Hemorrhage (ICH) is a destructive neurovascular disease with no efficient treatment. Trapped Red Blood Cells (RBCs) in the brain lyse releasing toxic heme from hemoglobin. Heme, a ...

During an immune response, macrophages systematically rewire their metabolism in specific ways to support their diversve functions. However, current knowledge of macrophage metabolism is largely ...

Introduction: PAH is associated with loss of pulmonary microvessels & vascular remodeling. Metabolic reprogramming(MR) characterized by high glycolysis & reduced FAO is hallmark feature of PAH linked ...

A recent publication in Cell demonstrates that arginine, an amino acid that facilitates various cellular processes, including cellular growth, also promotes tumor growth. The study shows that arginine ...

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Signaling rewiring allows tumors survive therapy. Here we show that the decrease of the master regulator microphthalmia transcription factor (MITF) in lethal prostate cancer (PCa) unleashes eukaryotic ...