Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic ...

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

Untreated atrial fibrillation carries an approximately 3 to 5% annual risk of ischemic stroke. Long-term oral anticoagulation therapy decreases this risk to 1.7% with warfarin and to 1.5% with ...

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 3).

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 23).

To the Editor: Morin and Buysse (July 18 issue) 1 provide a comprehensive overview of current assessments and treatments for insomnia. Their emphasis on cognitive behavioral therapy for insomnia as a ...

The CMS Innovation Center is approaching the next negotiation cycle for the CGT Access Model. Several considerations will guide the selection of future candidate diseases and potential new model ...

Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C (N Engl J Med 2023;389:2125-2139). As a result of late data entry, a reanalysis using a later data snapshot (March ...

A 44-year-old woman with recurrent oral aphthous ulcers presented with a progressively worsening papulopustular rash on her face and legs. Skin biopsy of a leg lesion revealed focal small-vessel va ...

To the Editor: Sanyal et al. (Oct. 21 issue)1 add important new data to our understanding of the natural course of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH). A substa ...

Explore this issue of The New England Journal of Medicine (Vol. 386 No. 1).