Pharmaceutical Technology on MSN
RNA-targeting small molecules: A new frontier of drug discovery
With big pharma signalling interest in novel RNA-targeted approaches, the term “druggable” is being redefined as technology ...
Researchers are embarking on the RNA equivalent of the Human Genome Project, including sequencing all the chemical ...
Morning Overview on MSN
Self-building RNA strand may expose how life on Earth truly began
Two separate laboratory breakthroughs have produced RNA molecules that can build copies of themselves or assemble functional structures without any help from proteins or DNA. These results offer the ...
The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi pathway. When miRNA acts as the guide for RNAi, only a ...
These random molecules were fed a collection of three-base-long RNAs, each linked to a chemical tag. The idea was that if a molecule is capable of ligating one of these short RNA fragments to itself, ...
40,000-year-old RNA from permafrost-preserved tissue was recovered from a mammoth specimen known as Yuka. Molecular evidence from Yuka revealed a correction to the original assumption about Yuka’s sex ...
A strand of RNA just 45 nucleotides long has been discovered to perform two key reactions required for self-replication. The ...
People are still debating whether the mRNA from COVID-19 vaccines remains in the body longer than it should. Some say it lingers and causes harm, others say that idea just doesn’t hold up. A new ...
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