Khachanov has been a Grand Slam semifinalist twice, at the US Open in 2022 and the Australian Open in 2023, but hasn't reached a quarterfinal since the 2023 French Open.

Zverev, the No. 1 seed because Carlos Alcaraz and Jannik Sinner skipped the event, is a -250 favorite to defeat Khachanov, who is looking for his first Masters 1000 title since 2018.