One year later, in these Hot Papers, Ramakrishnan's group described the complete structure of the 30S subunit at 3 Angstrom resolution, both isolated and complexed with antibiotics. This information ...

This image highlights two alternatives for the ribosome to be recruited to an mRNA that is still being synthesized by RNA polymerase (RNAP). RNAP (left, red) can directly deliver the mRNA to the entry ...

Evidence of human construction work is all around us: on the roads we travel, in the buildings we occupy and now even in outer space. But one form of “human construction” quietly does its job without ...

At the end of the 1970s, Ada Yonath decided she was going to generate crystal structures of the ribosome using x-ray crystallography to establish the exact location of every atom -- considered an ...

In the 1940s, scientists at the recently established National Cancer Institute were trying to breed mice that could inform our understanding of cancer, either because they predictably developed ...

Ribosomes—the tiny factories that build proteins in our cells—don't all work with the same efficiency. Researchers from Japan have discovered that ribosomes actually compete with one another, and ...

Members of NAI’s team at Georgia Tech have a new paper in Molecular Biology and Evolution describing an analysis of ribosomal structure and sequence. Their approach chronicles the ribosome’s evolution ...

In a recent study in Nature, researchers identified and characterized a broad-spectrum antibiotic, lariocidin (LAR). The antibiotic inhibits bacterial growth by altering protein synthesis in ribosomes ...

Protein folding helpers such as TRiC and prefoldin (PFD) are crucial for the correct folding of many essential proteins. In a Nature study, researchers from the Max Planck Institute of Biochemistry ...

Defects in ribosome biogenesis, assembly, and function of individual ribosomes are termed ribosomopathies. They are characterized by tissue-specific phenotypic abnormalities that consequently increase ...