Vaccinations have revolutionized healthcare, but designing them remains complex, requiring time and creativity, especially for vaccines against viruses, which are difficult to study. “Each virus ...

With the help of a technique called Massively Parallel Ribosome Profiling (MPRP), Shira Weingarten-Gabbay and colleagues identified more than 4000 open reading frames (ORFs) across 679 ...

These elusive sequences are known to impact viral replication, host immune responses, and gene regulation, yet their detection requires experimental methods beyond current computational tools.

This study illustrates how persistent mRNA rG4 structures induce ribosome pausing and collisions, leading to proteostasis collapse in senescent cells. The RNA helicase DHX9 acts as a key regulator, ...