Membrane receptors regulate numerous intracellular functions. However, the molecular underpinnings remain poorly understood because most receptors initiate multiple signaling pathways through distinct ...

G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...

From this core mechanism Fc engineering has evolved over time into the "engine" of therapeutic antibody development. It ...

Receptor tyrosine kinases (RTKs) regulate many critical biological processes such as cell growth, differentiation, and survival through the recruitment of intracellular signaling molecules. The ...

Many G protein-coupled receptor-mediated responses desensitize within minutes. Sustained stimulation of µ-opioid receptors (MORs), which primarily signal through Gi/o proteins, leads to activation and ...

A collaborative study on a plant intracellular immune receptor not only shows how an important resistance protein is activated during pathogen infection but also reveals some common operational ...

Bacteria use multiple defense mechanisms to survive in the host body. Shigella bacteria that cause colitis disable multiple ...

BCMA-directed cell therapy can offer a targeted mechanism of action that modulates myasthenia gravis pathology, Vu noted.

In a recent study published by Nature Communications, researchers uncovered a previously unknown method by which androgen-activated androgen receptors (ARs) increase fucosyltransferase 4 (FUT4) ...

A protein - measuring just a few nanometers in size - acts as a molecular switch with a crucial role in determining whether we feel hungry or full. By determining of the protein's 3D structure, ...