All cells within the same cancer are not the same. They all have genetic errors that turn them into tumor cells, but these errors are not identical. In each cancer, there are populations of cells with ...

Compound efficacy, specificity, accuracy, and in vivo relevance are key drivers in the decision-making process for progressing drug candidates through the lead-optimization phase into clinical trials.

Cell-based assays are used to study genes, proteins, and whole cellular functions, as well as the mechanisms that control them, by measuring specific cellular parameters. They have become an important ...

The disposition of antibody-based therapeutics is generally determined by both target-mediated and non-target processes, the latter being an often-overlooked aspect. Target-independent liabilities can ...

Evaluation of interferon-alfa 2b in a model of acute respiratory distress syndrome and pulmonary fibrosis induced by intratraqueal bleomycin in Wistar rats This is an ASCO Meeting Abstract from the ...

Cellular assays provide researchers with powerful insights into biological processes, including wound healing. However, scratch assays, the staple cell-based screening method in wound healing research ...