Can Spurs put their relegation fears to one side and take a big step towards the Champions League quarterfinals?

An incredibly dynamic City awaits... Semenyo, Doku, and Savinho is certainly a surprise from Guardiola, who appears to be favouring dynamism and instilling primal fear against Real Madrid's defensive unit.

For live updates and highlights throughout Real Madrid vs Manchester City, check out PST's live blog coverage below. Lineups TBA at 3 pm ET. Lineups TBA at 3 pm ET. Kick off time: 4pm ET Wednesday (March 11) Venue: Santiago Bernabeu — Madrid, Spain TV Channel / Streaming: Paramount+

Holders Paris Saint-Germain racked up an impressive 5-2 victory at home to Chelsea in their round of 16 first leg on Wednesday, while Federico Valverde scored a hat-trick as Real Madrid secured a three-goal cushion of their own against Man City.

Federico Valverde scored a sensational first-half hat-trick as injury-hit Real Madrid overpowered Manchester City 3-0 in the first leg of their Champions League last-16 tie.

Arsenal were staring at a first defeat of this season's Champions League at Bayer Leverkusen until a late penalty.

Real Madrid secured their spot in the Champions League Round of 16 following a 2-1 victory over Benfica at the Santiago Bernabeu.

Gabby Logan presents highlights of the first-leg ties from the Champions League round of 16. Arsenal, Liverpool, Tottenham, Chelsea, Manchester City and Newcastle are the six Premier League clubs in action alongside 15-time winners Real Madrid,

Bodo/Glimt continued their fairytale run in the UEFA Champions League with a clinical 3-0 victory over Sporting CP in the 1st leg of their round of 16 tie in front of home support

Manchester City's UEFA Champions League campaign is hanging by a thread after Federico Valverde bagged a first-half hat trick and Real Madrid took a commanding 3-0 lead in their round of 16 tie on Wednesday.