Centromeres are curious structures. These specially organized chromosomal regions are best known for their unique and critical role in cell division, in which they are well understood to serve as the ...

Researchers from the Kops group in collaboration with researchers from the University of Edinburgh, made a surprising new discovery in the structure of the centromere, a structure that is involved in ...

New research reveals that centromeres, which are responsible for proper cell division, can rapidly reorganize over short time scales. Biologists at the University of Rochester are calling a discovery ...

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities.

Since the 1800s, scientists have noted configuration of centromeres, a special chromosomal region that is vital for cell division, in the nucleus. Up until this point, however, the determining ...

In cells, CENP-A binds to histone H4 and HJURP before it is incorporated into the centromere. The previous model proposed that HJURP recognizes Mis18C and CENP-A is incorporated into the centromere ...

Super-resolution microscopy image of a mitotic chromosome (white) with the centromeres of each sister chromatid depicted in orange. Each centromere consists of two distinct chromatin subdomains ...

About a third to two-thirds down the shaft of a chromosome is a constricted site called the centromere. When a chromosome replicates, the old and new pair (called chromatids) are held together at this ...

A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of evolutionary change. Although centromeres are vital to proper cell replication ...

The Portuguese island of Madeira is home to six different chromosomal races of mice, each with dramatically reduced diploid chromosome numbers compared to mice elsewhere. This striking diversity, ...

Although centromeres are a defining feature of eukaryotic chromosomes, surprisingly little is known about how they are divided up into functional regions with distinct chromatin features. Now, the ...