The research was performed in the context of the ImmGenT project within the ImmGen consortium (supported by R24072073).

T cells are crucial components of our immune system, serving as critical protectors against infection and disease. But there ...

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells ...

INDIANAPOLIS — New research by the IU School of Medicine is looking at new ways to fight aggressive cancers. Right now the focus is on enhancing treatment options for aggressive cancers like triple ...

A new generation of CAR T cell therapy is bringing hope in the fight against cancer, targeting not only blood cancers but also solid tumors such as ovarian and breast cancer. Fraunhofer researchers ...

While modern life includes many conveniences, humans are still incessantly exposed to a variety of metabolic stresses we have ...

“While recent single-cell multiomics studies and CRISPR screens in murine NK cells have expanded our understanding, actionable genomic targets in primary human NK cells have remained largely ...

B cells are white blood cells that form a core part of the body's adaptive immune system, enabling it to recognize specific ...

This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic ...

Over the last decade, the cellular cancer immunotherapy known as CAR T-cell therapy has roared to the rescue of many blood cancer patients. The engineered immune cells revolutionized treatment of ...

As early results show promise, the 23-year-old hopes the treatment could finally clear a path toward his dream of becoming ...