Morning Overview on MSN

Researchers find some cancer drugs work differently than their stated targets

As of spring 2026, a cancer drug that has spent years in clinical development as a Wnt/beta-catenin pathway blocker has been ...
ascopubs.org

Phase 1/2 study of FOG-001, a first-in-class direct β-catenin:TCF inhibitor, in patients with colorectal cancer, hepatocellular carcinoma, and other locally advanced or ...

Phase 1/2 study of the HER3-directed antibody-drug conjugate patritumab deruxtecan (MK-1022) as monotherapy in patients with gastrointestinal cancers. This is an ASCO Meeting Abstract from the 2025 ...
Baylor College of Medicine

Surprising structure discovered in disordered protein

Inside each cell of the human body are proteins that control which genes are expressed at the right place and time. However, intriguingly, many of the most important proteins involved in gene ...
EurekAlert!

β-catenin/TCF4 is required for DDX17-induced epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

The diagram illustrates the key mechanisms of DDX17-induced hepatocellular carcinoma metastasis: DDX17 promotes nuclear translocation of β-catenin; in the nucleus, β-catenin forms a complex with TCF4, ...
Reuters

Avalon Pharma announces beta-catenin pathway inhibitors demonstrate significant tumor growth inhibition

Co announced that compounds from its Beta-catenin pathway inhibitor program demonstrated significant tumor growth inhibition in multiple animal models. The results will be presented today at the ...
Medical Xpress

Amino Acids, Peptides, and Proteins: News and Research on beta Catenin

Researchers at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS) have identified a small molecule that, in mouse and human cell models, rectifies the underlying ...